Dr. Lena Bouman

Lena Bouman studied biology in Marburg and Tübingen, focusing on cell biology and genetics. She was a visiting research fellow for a year at the Institut Curie in Paris as well as at the Rockefeller University in New York. During her doctorate at Ludwig-Maximilians-Universität in Munich (Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)), she worked on the molecular mechanisms of Parkinson's disease.

At the CAS, she is responsible for the natural sciences and medicine.

Publications

• Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.
  Bouman L., Schlierf A., Lutz A.K., Shan J., Deinlein A., Kast J., Galehdar Z., Palmisano V., Patenge N., Berg D., Gasser T., Augustin R., Trümbach D., Irrcher I., Park D.S., Wurst W., Kilberg M.S., Tatzelt J., Winklhofer K.F.
  Cell Death Differ. 2010 Nov 26.
• Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.
  Lutz A.K., Exner N., Fett M.E., Schlehe J.S., Kloos K., Lämmermann K., Brunner B., Kurz-Drexler A., Vogel F., Reichert A.S., Bouman L., Vogt-Weisenhorn D., Wurst W., Tatzelt J., Haass C., Winklhofer K.F.
  J Biol Chem. 2009 Aug 21;284(34):22938-51.
• Parkin mediates neuroprotection through activation of IKK/NF-κB signaling.
  Henn I.H., Bouman L., Schlehe J.S., Schlierf A., Schramm J.E., Nakaso K., Culmsee C., Berninger B., Krappmann D., Tatzelt J., Winklhofer K.F.
  J. Neurosci. 2007 Feb 21;27(8):1868-78.
• Ewing's sarcoma cells: up-regulation by interferon.
  Bouman L., Sanceau J., Rouillard D., Bauvois B. Gamma-Glutamyl transpeptidase expression in.
  Biochem J. 2002 Jun 15; 364(Pt 3):719-24.