Georg Küttinger: INTERFERENZEN 4-8, Detail (Art at CAS, Winter 2023/24)

Tools for Transnational Neuropsychiatric Research

Medicine | Academic Year 2023/2024

Clinical research on neurodegenerative and psychiatric disorders is extremely complex, as patient populations are diverse and heterogeneous. While molecular proof of pathological variants in specific genes has been found in a small subset of patients, widespread use of suitable biomarkers has not yet replaced the diagnostic gold standard of microscopic brain tissue examination to identify the causative pathologies. This examination is rarely performed on living subjects and not systematically conducted on deceased patients. Additionally, for many neurological and most psychiatric conditions, research has yet to produce biological markers that can be used in clinical care. However, genetically based cases of neuropsychiatric disorders offer a unique opportunity for more rigorous studies of natural history and treatment responses, as they constitute well-defined and homogeneous groups. These cases also offer a chance to better understand the biology of more heterogeneous disorders such as schizophrenia and dementia praecox, where subtle forms of neurodegeneration may exist in disease subgroups which could be identified using modern AI-powered pattern recognition methods.

To advance this field, the proposed research group will focus on four critical topics: (1) incentivization and governance of international consortia representing disease heterogeneity at a truly global level, (2) computerized approaches to cognitive testing and behavioral phenotyping, (3) language tests with cross-border, cross-cultural validity, and (4) the combination of "big data" and "deep data" analyses based on machine learning methods. By successfully developing research tools and solutions in these areas, the group aims to strengthen interdisciplinary neuropsychiatric research and complement ongoing approaches in the fields of biochemistry and brain imaging.

Spokespersons

Prof. Dr. Nikolaos Koutsouleris

LMU Munich

Spokesperson of the CAS Research Group “Tools for Transnational Neuropsychiatric Research“

Neuropsychiatry

Prof. Dr. Johannes Levin

LMU Munich

Spokesperson of the CAS Research Group “Tools for Transnational Neuropsychiatric Research“

Neurology

Members

Prof. Dr. Suvarna Alladi

National Institute of Mental Health and Neurosciences

Neurology

Mathilde Antoniades, Ph.D.

University of Pennsylvania

Neuroimaging

Graham Blackman, Ph.D.

University of Oxford

Psychiatry

Sterre de Boer

Amsterdam University Medical Centers

Neurology

Prof. em. Dr. Adrian Danek

LMU Hospital

Neurology

Prof. Christos Davatzikos, Ph.D.

University of Pennsylvania

Radiology

Prof. Juan Manuel Górriz, Ph.D.

University of Granada

Physics

Prof. Jason Hassenstab, Ph.D.

Washington University

Medicine

Laura del Hoyo Soriano, Ph.D.

Hospital de la Santa Creu i Sant Pau, Barcelona

Neuropsychology

Dr. Paris Alexandros Lalousis, Ph.D.

King's College London

Neuropsychology

Prof. Dr. Bernhard Landwehrmeyer

Ulm University

Neurology

Dr. Juan Fortea Mormaechea

Hospital de la Santa Creu i Sant Pau, Barcelona

Neurology

Francisco Martinez Murcia, Ph.D.

University of Granada

Medicine

Prof. Eric McDade, Ph.D.

Washington University

Neurology

Prof. Maxime Montembeault, Ph.D.

McGill University

Neuropsychology

Prof. Yolande Pijnenburg, Ph.D.

Amsterdam University Medical Centers

Medicine

Prof. Jonathan Rohrer, Ph.D.

University College London Hospitals

Neurology

Katja Sandkühler

LMU Hospital

Neuropsychology

Prof. Dr. Dr. Matthias Schroeter

MPI for Human Congnitive and Brain Sciences

Neuropsychiatry

Prof. Dennis Velakoulis, Ph.D.

Royal Melbourne Hospital

Neuropsychiatry

Events

Georg Küttinger: INTERFERENZEN 4-8, Detail (Art at CAS, Winter 2023/24)

Georg Küttinger: INTERFERENZEN 4-8, Detail

Georg Küttinger's work INTERFERENZEN 4-8 is part of his exhibition at CAS in winter 2023/24. © Tanja Mohr

Art at CAS